Normal CellsMUC1-N Physically Protects Cell Surface
MUC1-C is Activated in Response to Inflammation and Other Forms of Stress
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MUC1 Overexpressed in ~900,000 Tumors Diagnosed Each Year in the US
Breast, NSCLC, Prostate, Ovarian, Pancreatic, Colon and Hematologic Malignancies
MUC1 Expression Increased 50-100x In Cancer Cells MUC1 is Expressed in Solid Tumor and Leukemia Stem-like Cells Targeting MUC1-C Overcomes Drug Resistance Inhibition of MUC1-C Synergizes with Chemotherapeutics and Targeted Agents MUC1 Blocks Immune Recognition and Destruction |
Cancer CellsMUC1-N is shed from the tumor cell surface
MUC1-C Induces Proliferation
MUC1-C Blocks Cell Death |
Genus Oncology is Developing Multiple Approaches to Target the Non-Shed MUC1-C Subunit
Early attempts at targeting MUC1, particularly with antibodies, focused on MUC1-N and were ineffective because this subunit is shed from the cancer cell surface.
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