GENUS ONCOLOGY - THE MUC1-C COMPANY
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      • MUC1 Vaccine
      • MUC1-C in Stem-like Cells
      • MUC1-C inhibitor formulated in Nanoparticles
      • MUC1-C inhibitor is synergistic with chemotherapeutic and targeted drugs
      • MUC1-C is a druggable target

News

Paper published in “Biochimica et Biophysica Acta” describes how MUC1-C is involved in driving a program that integrates the induction of EMT with activation of stem cell traits, epigenetic reprogramming and immune evasion in human carcinomas.

3/14/2017

 
The MUC1-C-integrated program provides support for the importance of this oncoprotein in cancer progression and emphasizes a critical need for developing agents against this widely overexpressed target in human malignancies.
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Studies published in “Oncogene” have identified a highly important role for MUC1-C in activating a program of immune evasion in human cancer cells

3/13/2017

 
The findings show that MUC1-C drives PD-L1 expression and represses effectors, such as interferon-gamma among others, of innate and adaptive immunity.  Targeting MUC1-C in human cancers thus represents a novel therapeutic strategy for reversing tumor-associated suppression of immune recognition and destruction.
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  • Company
    • Mission
    • About Us
    • Genus Overview
    • Management
    • Board of Directors
    • Scientific Advisory Board
    • Clinical and Research Partners
    • Contact
    • Sitemap
  • Why Target MUC1-C?
  • Clinical Trials
    • Summary
    • GO-203
    • Phase 2 AML Clinical Trial
  • The Science
    • Overview
    • MUC1 in Human Cancer: The Numbers
    • MUC1 in Human Cancer: Overexpression
    • Target for Carcinoma Stem-Like Cell
    • Target for Leukemia Stem Cell
    • MUC1-C is an Attractive Target for Reversing Immune Evasion
    • Intellectual Property
  • Programs
    • Pipeline
    • Targeting the Cytoplasmic Domain
    • Targeting the Extracellular Domain
    • Biomarker Program
  • News & Publications
    • News
    • Publications >
      • Complete Listing
      • Role of MUC1-C in Signal Transduction
      • Role of MUC1-C in Epigenetic Regulation
      • Role of MUC1-C in Immune Evasion
      • MUC1 Vaccine
      • MUC1-C in Stem-like Cells
      • MUC1-C inhibitor formulated in Nanoparticles
      • MUC1-C inhibitor is synergistic with chemotherapeutic and targeted drugs
      • MUC1-C is a druggable target