Acute Myeloid Leukemia |
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MUC1 is aberrantly expressed in AML blasts and in AML stem cells.
Brossart P, Schneider A, Dill P, Grunebach F, Wirths S, Kanz L, Buhring H, and Brugger W, The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes. Cancer Res, 2001. 29:6846-50.
Fatrai S, Schepers H, Tadema H, Vellenga E, Daenen SM, and Schuringa JJ, Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases. Exp Hematol, 2008. 36:1254-65.
Stroopinsky D, Rosenblatt J, Ito K, Mills H, Yin L, Rajabi H, Vasir B, Kufe T, Luptakova K, Arnason J, Nardella C, Levine J, Joyce RM, Galinsky I, Reiter Y, Stone R, Pandolfi P, Kufe D, and Avigan D, MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells. Cancer Res, 2013. 73:5569-79.
Fatrai S, Schepers H, Tadema H, Vellenga E, Daenen SM, and Schuringa JJ, Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases. Exp Hematol, 2008. 36:1254-65.
Stroopinsky D, Rosenblatt J, Ito K, Mills H, Yin L, Rajabi H, Vasir B, Kufe T, Luptakova K, Arnason J, Nardella C, Levine J, Joyce RM, Galinsky I, Reiter Y, Stone R, Pandolfi P, Kufe D, and Avigan D, MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells. Cancer Res, 2013. 73:5569-79.